Abstract

Interleukin 13 (IL13) is an immunoregulatory cytokine which may decrease immunologic activity and secretion of proinflammatory cytokines. Cytokines have been known to be modulators of metabolic syndrome and insulin resistance. Polymorphisms of IL13 affect various disease including dermatologic, respiratory diseases, and asthma, which are linked to features of obesity, which is an origin of many stress factors. In this study, we conducted genetic association between IL13 polymorphisms (rs1800925, −1055C/T and rs1881457, −1510A/C) and dyslipidemia, hypertension, and obesity in a total of 265 subjects. The genotype of promoter SNP (rs1800925, −1055C/T) was associated to triglyceride (TG) level (codominant2 model, p=0.021; recessive model, p=0.022) and the genotypes and alleles of another promoter SNP (rs1881457, −1510A/C) were associated to hypertension (codominant2 model, p=0.013; recessive model, p=0.027; log-additive model, p=0.021; allele frequencies, p=0.017) and TG level (codominant2 model, p=0.021; recessive model, p=0.01). In conclusion, promoter polymorphisms (rs1800925 and rs1881457) of IL13 may be associated with the clinical features of metabolic syndrome patients, specially TG and hypertension. (Korean J Str Res 2013;21: 11∼165)

• Keywords: Dyslipidemia, Hypertension, Interleukin 13, Obesity, Promoter, Polymorphism