The purpose of this descriptive study was to investigate the effects of personality and coping behavior on clinical practice stress in nursing students which was experienced at clinical practice. The data were collected using questionnaire from the convenience sample of 88 nursing students. The data were collected from May 21 to 31, 2016. Data were analyzed with independent t-test, one way ANOVA, Pearson correlation coefficients, and multiple regression by using SPSS version 23.0. The mean score for clinical practice stress was 1.43±0.62, and the score for student domain (1.73±0.96) was the highest in clinical practice stress. Among the big five personality traits, neuroticism had positive correlation (r=.356, p=.001) with the clinical practice stress. Coping behavior (r=.285, p=.007) and passive coping behavior (r=.327, p=.002) also had positive correlation with the clinical practice stress in nursing students. The significant major predictors of clinical practice stress were neuroticism (β=.31) and passive coping behavior (β=.27). The explained variances for clinical practice stress was 18% in nursing students. Therefore, development of a program on enhancing personality and coping behavior to reduce clinical practice stress is needed.

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